Clozaril is a psychotropic medicine for the treatment of acute and chronic mental disorders. It has been approved by FDA in 1998 and is regarded as the first atypical neuroleptic on the pharmaceutical market. The drug contains Clozapine.


Clozaril has a broad action. Using the drug in the therapeutic doses, an intense sedative, somnific, antianxious, antipsychotic action. The drug also provides a moderate antimaniac action.


Unlike most strong neuroleptics (Seroquel, Zyprexa, and others), Clozaril does not cause side effects related to the motor disorders. These side effects are peculiar for all neuroleptics except Clozaril.


A pharmacological action of Clozaril is conditioned by the interaction with all neurotransmitters of the brain: serotonin, dopamine, receptors of histamine, muscarine receptors, monoamines, and others. But at the same time, Clozaril provides a strong inhibition of the psychomotor and physical function. A patient feels an evident sedative and antipsychotic action without reduced working capacity in 5-7 days.


Clozaril is prescribed for the treatment of such mental disorders as: acute and chronic forms of schizophrenia, mania, manic-depressive psychosis, agitation with psychopathy, emotional and behavioral disorders, insomnia, etc. Clozaril is also prescribed patients who have a resistance to other neuroleptics.


In what dose is Clozaril used?

The pills of Clozaril are used orally, after meals, 2-3 times per day. The drug provides a sharp and evident pharmacological action, and therefore the treatment should be used in the minimal doses.


To restore mental and emotional stability, patients are recommended to take Clozaril 25 mg 2 times per day. In 3-5 days, if the side effects are absent, a dose of Clozaril is gradually increased by 25 mg every 2-3 days. Doses lower than 100 mg per day may be used once per day before sleeping.


A standard therapeutic daily dose of Clozaril is 200-400 mg depending on a disease severity. After having a therapeutic effect, a maintaining dose of 100-200 mg per day is used, and the treatment is continued.



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  • When the treatment should be stopped, a dose is gradually reduced within 1-2 weeks. A sharp cessation may cause an acute condition of the mental disorder
  • If a patient has granulocytopenia or granulocytosis in anamnesis, the use of Clozaril is contraindicated
  • This drug is not recommended during stroke, myasthenia gravis, organic brain disease, coma, and cardiovascular diseases
  • Clozaril is not prescribed children under 16 years old, pregnant women and women during lactation
  • A systematic control of the peripheral blood is required during the treatment



Side effects

The use of Clozaril may be accompanied by the moderate side effects: sleepiness, headache, tachycardia, arterial hypotension, nausea, vomiting, granulocytopenia, and poor potency.


If the side effects are light, a medical aid is not required. If the side effects cause moral or physical discomfort, go to a doctor.


Buy Clozaril online

Clozaril is a strong neuroleptic which gives a strong action to the functions of the brain. That is why if you want to buy Clozaril online, thoroughly read an instruction for the use. If you want, you may contact a pharmacist of the online pharmacy, and s/he will provide a free medical consultation and tell how to take Clozaril without prescription.


A pharmacist’s consultation is not obligatory, and therefore you may buy Clozaril online right away. A shipment of Clozaril online is all over the world. Clozaril may be ordered online 24/7, at any time. You may buy Clozaril in the pharmacies of the city but, first of all, you need a prescription, and secondly, the drug will cost by 2 times higher in the city pharmacies than in the online ones.